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T7802 |
M1001
|
|
HIF/HIF Prolyl-Hydroxylase
,
HIF
|
|
M1001 is a HIF-2α agonist. |
|
T9022 |
AZD9977
|
AZD 9977 |
Glucocorticoid Receptor
|
|
AZD9977 is a novel, selective modulator of mineralocorticoid receptor . |
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T4583 |
PFI-2 hydrochloride
|
(R)-PFI-2 hydrochloride,PFI-2 HCl |
Histone Methyltransferase
|
|
PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2. |
|
T21395 |
Finerenone
|
BAY948862,BAY-948862,BAY94-8862,BAY 94-8862,BAY-94-8862,BAY 948862 |
Glucocorticoid Receptor
|
|
Finerenone (BAY-948862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment of chronic heart failure. Finerenone (BAY-948862... |
|
T6666 |
Sevelamer Carbonate
|
|
Others
|
|
Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. |
|
T1987 |
PFI-2
|
PFI2,PFI 2,(R)-PFI-2 |
Histone Methyltransferase
|
|
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. |
|
T13591 |
Calcium polystyrene sulfonate
|
Poly(styrenesulfonic acid) calcium salt |
Others
|
|
Calcium polystyrene sulfonate (Poly(styrenesulfonic acid) calcium salt) is an ion-exchange resin. Calcium polystyrene sulfonate reduces blood levels of potassium and can be used for research on the treatment of hyperkale... |
|
T30479 |
Bis-T-23
|
Bis T-23,Bis-T 23,AG1717 |
HIV Protease
|
|
Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV... |
|
T13604 |
CDDO-dhTFEA
|
|
Others
,
NF-κB
,
Nrf2
|
|
CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expressi... |
|
T28222 |
5-Hydroxy-1-methylhydantoin
|
HD-003,HD003,NZ419,NZ-419,HD 003,NZ 419 |
Bradykinin Receptor
|
|
5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to con... |
|
T32193 |
Iron sorbitex
|
Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572 |
|
|
Iron Sorbitex is used for the treatment of Iron Sorbitex deficiency anemia in patients with chronic kidney disease. Iron Sorbitex can be used as an Iron Sorbitex replacement product used for the treatment of Iron Sorbite... |
|
T39410 |
Zevaquenabant
|
(S)-MRI-1867 |
|
|
Zevaquenabant ((S)-MRI-1867), a dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist, is orally bioavailable and peripherally restricted. It effectively mitigates obesity-induced chronic kidney disease (CKD)... |
|
T38419 |
Difelikefalin
|
CR-845,FE-202845 |
|
|
Difelikefalin (CR-845; FE-202845) is a peripherally restricted, selective agonist of the kappa opioid receptor (KOR). It exhibits anti-inflammatory properties and holds promise for modulating pruritus in conditions assoc... |
|
T60937 |
TRPC5-IN-1
|
|
|
|
TRPC5-IN-1 is a TRPC5 inhibitor active in various animal models of chronic kidney disease. |
|
T73332 |
BI-685509
|
|
|
|
BI-685509 is a potent and orally active sGC activator. BI-685509 restores cyclic guanosine monophosphate (cGMP) and improves functionality of nitric oxide (NO) pathways. BI-685509 can be used in research of chronic kidne... |
|
T69294 |
UK‑396082
|
|
|
|
UK-396082 is a potent inhibitor of thrombin-activated fibrinolytic inhibitor (TAFI), enhancing plasmin activity while concurrently reducing levels of the extracellular matrix (ECM). This compound is valuable for research... |
|
T76947 |
Ziltivekimab
|
|
|
|
Ziltivekimab (COR-001), a human anti-IL-6 monoclonal antibody, efficiently lowers serum CRP levels and exhibits anti-inflammatory properties. It is potentially useful in researching chronic systemic inflammation and card... |
|
T80220 |
OK2
|
|
EGFR
|
|
OK2, a specific inhibitor of the CCN2/EGFR interaction, effectively disrupts this interaction by binding to the CT domain of CCN2. It holds potential for use in research pertaining to kidney fibrosis and chronic kidney d... |
|
T62589 |
TRPC5-IN-4
|
|
|
|
TRPC5-IN-4, a potent and safe TRPC inhibitor, exhibits IC50 values of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively, indicating high efficacy. It does not cause damage to liver and kidney cellular components, maki... |
|
T60640 |
SSAO inhibitor-2
|
|
|
|
SSAO inhibitor-2 (Compound 1) can be used in the research of atherosclerosis, diabetes and its complications, obesity, stroke, chronic kidney disease, retinopathy, chronic obstructive pulmonary disease (COPD), autoimmune... |
|
T78513 |
Sodium zirconium cyclosilicate
|
|
Others
|
|
Sodium zirconium cyclosilicate, an orally administered, non-absorbed, microporous zirconium silicate, acts as a highly selective cation exchanger to remove excess potassium (K+) in vivo. It has potential use in the resea... |
|
T60909 |
SSAO inhibitor-3
|
|
|
|
SSAO inhibitor-3 (Compound 2) can be used in the study of atherosclerosis, diabetes and its complications, obesity, stroke, chronic kidney disease, retinopathy, chronic obstructive pulmonary disease (COPD), autoimmune di... |
|
T36384 |
DL-Tyrosine-13C9,15N
|
L-Tyrosine-13C9,15N |
|
|
L-Tyrosine-13C9,15N is intended for use as an internal standard for the quantification of L-tyrosine by GC- or LC-MS. L-Tyrosine is a non-essential amino acid.1It is produced by hydroxylation of phenylalanine by phenylal... |
|
T83872 |
Oleoyl-L-carnitine chloride
|
L-Carnitine oleoyl ester,L-Octadecanoylcarnitine,C18:1 Carnitine,CAR 18:1 |
|
|
Oleoyl-L-carnitine, a long-chain acylcarnitine, acts as a selective inhibitor of glycine transporter 2 (GlyT2; IC50 = 340 nM) while demonstrating significantly lesser affinity for GlyT1 (IC50 = >10,000 nM). Elevated plas... |
|
T35881 |
Resolvin E2
|
|
|
|
Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-... |
|
T69966 |
Roxadustat-d5
|
|
|
|
Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.... |
|
T83763 |
EPI-X4 TFA
|
Endogenous Peptide Inhibitor of CXCR4 |
|
|
EPI-X4, an endogenous peptide fragment of human serum albumin (amino acids 408-423), serves as an antagonist to the chemokine (C-X-C motif) receptor 4 (CXCR4). It effectively prevents calcium mobilization and receptor in... |
